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Re: Vaccinations

Newsgroups sci.electronics.design
Subject Re: Vaccinations
References <o7b5h7$v3f$1@dont-email.me> <o7dbeo$28d$1@dont-email.me> <tkvk9cp3c499feqsjpeo919rn9bj9n5ug3@4ax.com> <o7f7bv$9j9$1@dont-email.me>
From dplatt@coop.radagast.org (Dave Platt)
Date 2017-02-08 11:33 -0800
Message-ID <sd8smd-ei5.ln1@coop.radagast.org> (permalink)
Organization Unlimited download news at news.astraweb.com

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In article <o7f7bv$9j9$1@dont-email.me>, amdx  <nojunk@knology.net> wrote:

>> My wife had shingles a year, or so, ago.  She then got the vaccination
>> so she wouldn't get it again.  The vaccination was almost as bad as
>> the shingles.
>
>   So can I deduce from this that, you don't develop immunity from 
>shingles by having shingles?
>  If that is the case, how does the vaccination work?

"Immunity" is not an all-or-nothing sort of thing.  It's a
proportional thing.  The better your body is at recognizing "foreign"
antigens, and the faster it can gear up to product antibodies, and the
more correctly-structured the antibodies, the better the body can
resist the infection.

If you've had chickenpox, you very probably have "latent" virus
lurking in your nervous system.  You'll have developed antibodies
against this virus (and the specific B cells "programmed" to generate
them when stimulated), but the levels of both the antibodies, and the
number of properly-programmed B cells will decline with time.

If the virus comes out of latency, it will tend to spread along the
nerve fibers and cause shingles.  Antibodies seem to have some
difficulty working quickly against herpesviruses in the nerves (not
certain why but I suspect it's at least partly because nerves aren't
directly exposed to the bloodstream) and it takes a while for enough B
cells to "wake up" and start producing effective antibodies again.

This is why having had chickenpox, or an earlier outbreak of shingles,
isn't a 100% guarantee that you won't have a shingles outbreak... the
body's own immune system isn't fully effective.

The shingles vaccine acts to "re-prime" the immune system:  causing
enough of an immune reaction against the injected virus components to
"recruit" a new generation of properly-programmed B cells to create
antibodies against the virus.

This doesn't guarantee absolute protection against viruses which "come
out of latency" and start to spread along the nerves, but it does
help.  If I recall correctly, the vaccination reduces the number of
shingles attacks by about 50%, and also helps to reduce the severity
of those outbreaks which do occur.

It's sorta like doing a good warmup before going for a run.  Doing
your warmup properly doesn't _guarantee_ that you won't pull a muscle
or tear a tendon, but it significantly improves your odds.

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Thread

Vaccinations Don Y <blockedofcourse@foo.invalid> - 2017-02-06 17:50 -0700
  Re: Vaccinations bill.sloman@ieee.org - 2017-02-06 16:55 -0800
    Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-06 21:26 -0500
  Re: Vaccinations Jim Thompson <To-Email-Use-The-Envelope-Icon@On-My-Web-Site.com> - 2017-02-06 17:56 -0700
    Re: Vaccinations "dcaster@krl.org" <dcaster@krl.org> - 2017-02-06 17:01 -0800
    Re: Vaccinations Don Y <blockedofcourse@foo.invalid> - 2017-02-06 18:04 -0700
    Re: Vaccinations Sylvia Else <sylvia@not.at.this.address> - 2017-02-07 12:21 +1100
      Re: Vaccinations Jim Thompson <To-Email-Use-The-Envelope-Icon@On-My-Web-Site.com> - 2017-02-06 18:57 -0700
        Re: Vaccinations Sylvia Else <sylvia@not.at.this.address> - 2017-02-07 13:17 +1100
          Re: Vaccinations Rheilly Phoull <rheilly@bigslong.com> - 2017-02-07 10:22 +0800
          Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-06 21:35 -0500
            Re: Vaccinations Sylvia Else <sylvia@not.at.this.address> - 2017-02-07 13:39 +1100
              Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-06 23:31 -0500
          Re: Vaccinations Martin Riddle <martin_ridd@verizon.net> - 2017-02-06 22:47 -0500
          Re: Vaccinations John Larkin <jjlarkin@highlandtechnology.com> - 2017-02-06 20:46 -0800
            Re: Vaccinations bloggs.fredbloggs.fred@gmail.com - 2017-02-07 02:20 -0800
            Re: Vaccinations dplatt@coop.radagast.org (Dave Platt) - 2017-02-07 11:30 -0800
              Re: Vaccinations John Larkin <jjlarkinxyxy@highlandtechnology.com> - 2017-02-07 12:03 -0800
                Re: Vaccinations Reinhardt Behm <rbehm@hushmail.com> - 2017-02-08 18:22 +0800
                Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-08 05:23 -0500
                Re: Vaccinations Reinhardt Behm <rbehm@hushmail.com> - 2017-02-08 18:39 +0800
                Re: Vaccinations bill.sloman@ieee.org - 2017-02-08 06:12 -0800
                Re: Vaccinations David Brown <david.brown@hesbynett.no> - 2017-02-08 15:38 +0100
                Re: Vaccinations M Philbrook <jamie_ka1lpa@charter.net> - 2017-02-09 19:27 -0500
                Re: Vaccinations bill.sloman@ieee.org - 2017-02-09 16:59 -0800
                Re: Vaccinations bill.sloman@ieee.org - 2017-02-08 06:09 -0800
                Re: Vaccinations David Brown <david.brown@hesbynett.no> - 2017-02-08 15:39 +0100
                Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-08 17:05 -0500
        Re: Vaccinations Martin Riddle <martin_ridd@verizon.net> - 2017-02-06 22:45 -0500
        Re: Vaccinations Tom Gardner <spamjunk@blueyonder.co.uk> - 2017-02-07 08:21 +0000
    Re: Vaccinations Tom Gardner <spamjunk@blueyonder.co.uk> - 2017-02-07 08:19 +0000
      Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-07 04:20 -0500
        Re: Vaccinations Tom Gardner <spamjunk@blueyonder.co.uk> - 2017-02-07 09:42 +0000
    Re: Vaccinations Cursitor Doom <curd@notformail.com> - 2017-02-07 17:57 +0000
      Re: Vaccinations Jim Thompson <To-Email-Use-The-Envelope-Icon@On-My-Web-Site.com> - 2017-02-07 11:12 -0700
        Re: Vaccinations "tom" <tmiller11147@verizon.net> - 2017-02-07 15:43 -0500
          Re: Vaccinations krw@notreal.com - 2017-02-07 21:15 -0500
            Re: Vaccinations amdx <nojunk@knology.net> - 2017-02-08 07:46 -0600
              Re: Vaccinations krw@notreal.com - 2017-02-08 12:45 -0500
              Re: Vaccinations dplatt@coop.radagast.org (Dave Platt) - 2017-02-08 11:33 -0800
                Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-08 17:19 -0500
            Re: Vaccinations Cursitor Doom <curd@notformail.com> - 2017-02-08 17:57 +0000
              Re: Vaccinations krw@notreal.com - 2017-02-08 13:16 -0500
                Re: Vaccinations Martin Brown <|||newspam|||@nezumi.demon.co.uk> - 2017-02-08 18:32 +0000
                Re: Vaccinations Don Y <blockedofcourse@foo.invalid> - 2017-02-08 12:09 -0700
        Re: Vaccinations John Devereux <john@devereux.me.uk> - 2017-02-07 21:08 +0000
          Re: Vaccinations David Brown <david.brown@hesbynett.no> - 2017-02-08 12:45 +0100
            Re: Vaccinations Cursitor Doom <curd@notformail.com> - 2017-02-08 18:00 +0000
              Re: Vaccinations krw@notreal.com - 2017-02-08 13:16 -0500
                Re: Vaccinations Jim Thompson <To-Email-Use-The-Envelope-Icon@On-My-Web-Site.com> - 2017-02-08 11:28 -0700
                Re: Vaccinations krw@notreal.com - 2017-02-08 20:33 -0500
              Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-08 17:26 -0500
                Re: Vaccinations Cursitor Doom <curd@notformail.com> - 2017-02-08 23:09 +0000
                Re: Vaccinations Lasse Langwadt Christensen <langwadt@fonz.dk> - 2017-02-08 15:33 -0800
                Re: Vaccinations bill.sloman@ieee.org - 2017-02-08 15:42 -0800
                Re: Vaccinations Tom Gardner <spamjunk@blueyonder.co.uk> - 2017-02-08 23:43 +0000
                Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-08 20:56 -0500
                Re: Vaccinations David Brown <david.brown@hesbynett.no> - 2017-02-09 10:58 +0100
                Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-09 05:35 -0500
                Re: Vaccinations David Brown <david.brown@hesbynett.no> - 2017-02-09 12:54 +0100
                Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-09 07:20 -0500
                Re: Vaccinations Tom Gardner <spamjunk@blueyonder.co.uk> - 2017-02-09 13:38 +0000
                Re: Vaccinations David Brown <david.brown@hesbynett.no> - 2017-02-09 14:56 +0100
                Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-09 17:47 -0500
                Re: Vaccinations bill.sloman@ieee.org - 2017-02-09 17:16 -0800
                Re: Vaccinations Tom Gardner <spamjunk@blueyonder.co.uk> - 2017-02-09 16:40 +0000
                Re: Vaccinations amdx <nojunk@knology.net> - 2017-02-09 11:04 -0600
                Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-09 17:46 -0500
                Re: Vaccinations amdx <nojunk@knology.net> - 2017-02-09 09:15 -0600
                Re: Vaccinations Cursitor Doom <curd@notformail.com> - 2017-02-10 16:36 +0000
                Re: Vaccinations bill.sloman@ieee.org - 2017-02-10 16:41 -0800
          Re: Vaccinations John Larkin <jjlarkin@highlandtechnology.com> - 2017-02-08 09:12 -0800
            Re: Vaccinations Lasse Langwadt Christensen <langwadt@fonz.dk> - 2017-02-08 09:36 -0800
              Re: Vaccinations John Larkin <jjlarkinxyxy@highlandtechnology.com> - 2017-02-08 12:40 -0800
            Re: Vaccinations Don Y <blockedofcourse@foo.invalid> - 2017-02-08 11:51 -0700
            Re: Vaccinations John Devereux <john@devereux.me.uk> - 2017-02-09 15:02 +0000
              Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-09 17:46 -0500
                Re: Vaccinations Cursitor Doom <curd@notformail.com> - 2017-02-10 16:52 +0000
                Re: Vaccinations bill.sloman@ieee.org - 2017-02-10 16:46 -0800
              Re: Vaccinations krw@notreal.com - 2017-02-09 21:12 -0500
                Re: Vaccinations bill.sloman@ieee.org - 2017-02-09 19:01 -0800
                Re: Vaccinations John Devereux <john@devereux.me.uk> - 2017-02-10 08:23 +0000
                Re: Vaccinations krw@notreal.com - 2017-02-10 12:23 -0500
                Re: Vaccinations John Devereux <john@devereux.me.uk> - 2017-02-10 18:09 +0000
      Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-07 16:31 -0500
  Re: Vaccinations artie <artie.m@gNOSPAMmail.com> - 2017-02-06 17:28 -0800
    Re: Vaccinations Don Y <blockedofcourse@foo.invalid> - 2017-02-06 19:11 -0700
      Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-06 21:34 -0500
  Re: Vaccinations Frank Miles <fpm@u.washington.edu> - 2017-02-07 01:52 +0000

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