Groups > sci.electronics.design > #446884

Re: Vaccinations

From	rickman <gnuarm@gmail.com>
Newsgroups	sci.electronics.design
Subject	Re: Vaccinations
Date	2017-02-08 17:19 -0500
Organization	A noiseless patient Spider
Message-ID	<o7g5f2$1ps$1@dont-email.me> (permalink)
References	<o7b5h7$v3f$1@dont-email.me> <o7dbeo$28d$1@dont-email.me> <tkvk9cp3c499feqsjpeo919rn9bj9n5ug3@4ax.com> <o7f7bv$9j9$1@dont-email.me> <sd8smd-ei5.ln1@coop.radagast.org>

Show all headers | View raw

On 2/8/2017 2:33 PM, Dave Platt wrote:
> In article <o7f7bv$9j9$1@dont-email.me>, amdx  <nojunk@knology.net> wrote:
>
>>> My wife had shingles a year, or so, ago.  She then got the vaccination
>>> so she wouldn't get it again.  The vaccination was almost as bad as
>>> the shingles.
>>
>>   So can I deduce from this that, you don't develop immunity from
>> shingles by having shingles?
>>  If that is the case, how does the vaccination work?
>
> "Immunity" is not an all-or-nothing sort of thing.  It's a
> proportional thing.  The better your body is at recognizing "foreign"
> antigens, and the faster it can gear up to product antibodies, and the
> more correctly-structured the antibodies, the better the body can
> resist the infection.
>
> If you've had chickenpox, you very probably have "latent" virus
> lurking in your nervous system.  You'll have developed antibodies
> against this virus (and the specific B cells "programmed" to generate
> them when stimulated), but the levels of both the antibodies, and the
> number of properly-programmed B cells will decline with time.
>
> If the virus comes out of latency, it will tend to spread along the
> nerve fibers and cause shingles.  Antibodies seem to have some
> difficulty working quickly against herpesviruses in the nerves (not
> certain why but I suspect it's at least partly because nerves aren't
> directly exposed to the bloodstream) and it takes a while for enough B
> cells to "wake up" and start producing effective antibodies again.
>
> This is why having had chickenpox, or an earlier outbreak of shingles,
> isn't a 100% guarantee that you won't have a shingles outbreak... the
> body's own immune system isn't fully effective.
>
> The shingles vaccine acts to "re-prime" the immune system:  causing
> enough of an immune reaction against the injected virus components to
> "recruit" a new generation of properly-programmed B cells to create
> antibodies against the virus.
>
> This doesn't guarantee absolute protection against viruses which "come
> out of latency" and start to spread along the nerves, but it does
> help.  If I recall correctly, the vaccination reduces the number of
> shingles attacks by about 50%, and also helps to reduce the severity
> of those outbreaks which do occur.
>
> It's sorta like doing a good warmup before going for a run.  Doing
> your warmup properly doesn't _guarantee_ that you won't pull a muscle
> or tear a tendon, but it significantly improves your odds.

Shingles lies dormant in the nerves.  There is no reason to believe it 
doesn't challenge the immune system at a low level continuously or at 
least periodically.  Once the immune system is suppressed for any of a 
number of reasons, old age, other illness, taking immunosuppressant 
drugs, etc., the disease can be expressed.

Anti-bodies don't fight diseases in the nerves because they travel in 
the bloodstream.  This is true for many diseases.  But disease is 
usually spread in the bloodstream, so anti-bodies in the bloodstream 
prevent migration of the disease that way.

-- 

Rick C

Thread

Vaccinations Don Y <blockedofcourse@foo.invalid> - 2017-02-06 17:50 -0700
  Re: Vaccinations bill.sloman@ieee.org - 2017-02-06 16:55 -0800
    Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-06 21:26 -0500
  Re: Vaccinations Jim Thompson <To-Email-Use-The-Envelope-Icon@On-My-Web-Site.com> - 2017-02-06 17:56 -0700
    Re: Vaccinations "dcaster@krl.org" <dcaster@krl.org> - 2017-02-06 17:01 -0800
    Re: Vaccinations Don Y <blockedofcourse@foo.invalid> - 2017-02-06 18:04 -0700
    Re: Vaccinations Sylvia Else <sylvia@not.at.this.address> - 2017-02-07 12:21 +1100
      Re: Vaccinations Jim Thompson <To-Email-Use-The-Envelope-Icon@On-My-Web-Site.com> - 2017-02-06 18:57 -0700
        Re: Vaccinations Sylvia Else <sylvia@not.at.this.address> - 2017-02-07 13:17 +1100
          Re: Vaccinations Rheilly Phoull <rheilly@bigslong.com> - 2017-02-07 10:22 +0800
          Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-06 21:35 -0500
            Re: Vaccinations Sylvia Else <sylvia@not.at.this.address> - 2017-02-07 13:39 +1100
              Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-06 23:31 -0500
          Re: Vaccinations Martin Riddle <martin_ridd@verizon.net> - 2017-02-06 22:47 -0500
          Re: Vaccinations John Larkin <jjlarkin@highlandtechnology.com> - 2017-02-06 20:46 -0800
            Re: Vaccinations bloggs.fredbloggs.fred@gmail.com - 2017-02-07 02:20 -0800
            Re: Vaccinations dplatt@coop.radagast.org (Dave Platt) - 2017-02-07 11:30 -0800
              Re: Vaccinations John Larkin <jjlarkinxyxy@highlandtechnology.com> - 2017-02-07 12:03 -0800
                Re: Vaccinations Reinhardt Behm <rbehm@hushmail.com> - 2017-02-08 18:22 +0800
                Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-08 05:23 -0500
                Re: Vaccinations Reinhardt Behm <rbehm@hushmail.com> - 2017-02-08 18:39 +0800
                Re: Vaccinations bill.sloman@ieee.org - 2017-02-08 06:12 -0800
                Re: Vaccinations David Brown <david.brown@hesbynett.no> - 2017-02-08 15:38 +0100
                Re: Vaccinations M Philbrook <jamie_ka1lpa@charter.net> - 2017-02-09 19:27 -0500
                Re: Vaccinations bill.sloman@ieee.org - 2017-02-09 16:59 -0800
                Re: Vaccinations bill.sloman@ieee.org - 2017-02-08 06:09 -0800
                Re: Vaccinations David Brown <david.brown@hesbynett.no> - 2017-02-08 15:39 +0100
                Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-08 17:05 -0500
        Re: Vaccinations Martin Riddle <martin_ridd@verizon.net> - 2017-02-06 22:45 -0500
        Re: Vaccinations Tom Gardner <spamjunk@blueyonder.co.uk> - 2017-02-07 08:21 +0000
    Re: Vaccinations Tom Gardner <spamjunk@blueyonder.co.uk> - 2017-02-07 08:19 +0000
      Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-07 04:20 -0500
        Re: Vaccinations Tom Gardner <spamjunk@blueyonder.co.uk> - 2017-02-07 09:42 +0000
    Re: Vaccinations Cursitor Doom <curd@notformail.com> - 2017-02-07 17:57 +0000
      Re: Vaccinations Jim Thompson <To-Email-Use-The-Envelope-Icon@On-My-Web-Site.com> - 2017-02-07 11:12 -0700
        Re: Vaccinations "tom" <tmiller11147@verizon.net> - 2017-02-07 15:43 -0500
          Re: Vaccinations krw@notreal.com - 2017-02-07 21:15 -0500
            Re: Vaccinations amdx <nojunk@knology.net> - 2017-02-08 07:46 -0600
              Re: Vaccinations krw@notreal.com - 2017-02-08 12:45 -0500
              Re: Vaccinations dplatt@coop.radagast.org (Dave Platt) - 2017-02-08 11:33 -0800
                Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-08 17:19 -0500
            Re: Vaccinations Cursitor Doom <curd@notformail.com> - 2017-02-08 17:57 +0000
              Re: Vaccinations krw@notreal.com - 2017-02-08 13:16 -0500
                Re: Vaccinations Martin Brown <|||newspam|||@nezumi.demon.co.uk> - 2017-02-08 18:32 +0000
                Re: Vaccinations Don Y <blockedofcourse@foo.invalid> - 2017-02-08 12:09 -0700
        Re: Vaccinations John Devereux <john@devereux.me.uk> - 2017-02-07 21:08 +0000
          Re: Vaccinations David Brown <david.brown@hesbynett.no> - 2017-02-08 12:45 +0100
            Re: Vaccinations Cursitor Doom <curd@notformail.com> - 2017-02-08 18:00 +0000
              Re: Vaccinations krw@notreal.com - 2017-02-08 13:16 -0500
                Re: Vaccinations Jim Thompson <To-Email-Use-The-Envelope-Icon@On-My-Web-Site.com> - 2017-02-08 11:28 -0700
                Re: Vaccinations krw@notreal.com - 2017-02-08 20:33 -0500
              Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-08 17:26 -0500
                Re: Vaccinations Cursitor Doom <curd@notformail.com> - 2017-02-08 23:09 +0000
                Re: Vaccinations Lasse Langwadt Christensen <langwadt@fonz.dk> - 2017-02-08 15:33 -0800
                Re: Vaccinations bill.sloman@ieee.org - 2017-02-08 15:42 -0800
                Re: Vaccinations Tom Gardner <spamjunk@blueyonder.co.uk> - 2017-02-08 23:43 +0000
                Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-08 20:56 -0500
                Re: Vaccinations David Brown <david.brown@hesbynett.no> - 2017-02-09 10:58 +0100
                Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-09 05:35 -0500
                Re: Vaccinations David Brown <david.brown@hesbynett.no> - 2017-02-09 12:54 +0100
                Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-09 07:20 -0500
                Re: Vaccinations Tom Gardner <spamjunk@blueyonder.co.uk> - 2017-02-09 13:38 +0000
                Re: Vaccinations David Brown <david.brown@hesbynett.no> - 2017-02-09 14:56 +0100
                Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-09 17:47 -0500
                Re: Vaccinations bill.sloman@ieee.org - 2017-02-09 17:16 -0800
                Re: Vaccinations Tom Gardner <spamjunk@blueyonder.co.uk> - 2017-02-09 16:40 +0000
                Re: Vaccinations amdx <nojunk@knology.net> - 2017-02-09 11:04 -0600
                Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-09 17:46 -0500
                Re: Vaccinations amdx <nojunk@knology.net> - 2017-02-09 09:15 -0600
                Re: Vaccinations Cursitor Doom <curd@notformail.com> - 2017-02-10 16:36 +0000
                Re: Vaccinations bill.sloman@ieee.org - 2017-02-10 16:41 -0800
          Re: Vaccinations John Larkin <jjlarkin@highlandtechnology.com> - 2017-02-08 09:12 -0800
            Re: Vaccinations Lasse Langwadt Christensen <langwadt@fonz.dk> - 2017-02-08 09:36 -0800
              Re: Vaccinations John Larkin <jjlarkinxyxy@highlandtechnology.com> - 2017-02-08 12:40 -0800
            Re: Vaccinations Don Y <blockedofcourse@foo.invalid> - 2017-02-08 11:51 -0700
            Re: Vaccinations John Devereux <john@devereux.me.uk> - 2017-02-09 15:02 +0000
              Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-09 17:46 -0500
                Re: Vaccinations Cursitor Doom <curd@notformail.com> - 2017-02-10 16:52 +0000
                Re: Vaccinations bill.sloman@ieee.org - 2017-02-10 16:46 -0800
              Re: Vaccinations krw@notreal.com - 2017-02-09 21:12 -0500
                Re: Vaccinations bill.sloman@ieee.org - 2017-02-09 19:01 -0800
                Re: Vaccinations John Devereux <john@devereux.me.uk> - 2017-02-10 08:23 +0000
                Re: Vaccinations krw@notreal.com - 2017-02-10 12:23 -0500
                Re: Vaccinations John Devereux <john@devereux.me.uk> - 2017-02-10 18:09 +0000
      Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-07 16:31 -0500
  Re: Vaccinations artie <artie.m@gNOSPAMmail.com> - 2017-02-06 17:28 -0800
    Re: Vaccinations Don Y <blockedofcourse@foo.invalid> - 2017-02-06 19:11 -0700
      Re: Vaccinations rickman <gnuarm@gmail.com> - 2017-02-06 21:34 -0500
  Re: Vaccinations Frank Miles <fpm@u.washington.edu> - 2017-02-07 01:52 +0000

csiph-web