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Risikogruppe Raucher

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https://www.preprints.org/manuscript/202004.0540/v1

| What is Happening with Smokers and COVID-19? A Systematic Review and a
| Meta-Analysis
|
| SARS-CoV-2 is a new coronavirus that has caused a worldwide pandemic.
| It produces severe acute respiratory disease (COVID-19), which is
| fatal in many cases, characterised by cytokine release syndrome (CRS).
| According to the World Health Organization (WHO), those who smoke are
| likely to be more vulnerable to infection. Here, in order to clarify
| the epidemiologic relationship between smoking and COVID-19, we
| present a systematic literature review until 28 April 2020 and a meta-
| analysis. It includes 18 recent COVID-19 clinical and epidemiological
| studies based on smoking patient status from 720 initial studies in
| China, USA, and Italy. The percentage of hospitalised current smokers
| was 7.7% (95%CI: 6.9-8.4) in China, 2.3% (95%CI: 1.7-2.9) in the USA
| and 7.6% (95%CI: 4.2-11.0) in Italy. These percentages were compared
| to the smoking prevalence of each country and statistically
| significant differences were found in them all (p <0.0001). By means
| of the meta-analysis, we offer epidemiological evidence showing that
| smokers were statistically less likely to be hospitalised (OR=0.18,
| 95%CI: 0.14-0.23, p<0.01). CRS and exacerbated inflammatory response
| are associated with aggravation of hospitalise patients. In this
| scenario, we hypothesise that nicotine, not smoking, could ameliorate
| the cytokine storm and severe related inflammatory response through
| the cholinergic-mediated anti-inflammatory pathway.

https://www.qeios.com/read/WPP19W.4

| Low rate of daily active tobacco smoking in patients with symptomatic
| COVID-19
|
| Results: The inpatient group was composed of 340 patients, median age
| 66 years: 203 men (59.7%, median age 66 years) and 137 women (40.3%,
| median age 66 years),with a rate of daily smokers of 4.1% CI95% [2.3 –
| 6.9] (5.4% of men and 2.2% of women). The outpatient group was
| composed of 139 patients, median age 44 years: 62 men (44.6%, median
| age 43 years, and 77 women (55.4 %, median age 44 years). The daily
| smokers’ rate was 6.1 % CI95% [2.7 - 11.6] (5.1% of men and 6.8 % of
| women). In the French population, the daily smokers’ rate was 25.4%
| (28.2% of men and 22.9% of women).
|
| The rate of daily smokers was significantly lower in COVID-19
| patients, as compared to that in the French general population after
| standardization by age and sex, with Standardized Incidence Ratios of
| 0.23 [0.11 - 0.45] for outpatients and 0.23 [0.14 - 0.39] for
| inpatients. These ratios did not significantly differ between the two
| groups (P=0.94).
|
| Conclusions and relevance: This cross sectional study in both COVID-19
| out- and inpatients shows that daily smokers rate in patients with
| symptomatic COVID-19 is lower as compared to the general population.
-- 
"Der Hund hat gerade die Probepackung vegetarisches Futter neben den 
Mülleimer gekotzt. Auf Amazon wäre das ★☆☆☆☆"
                                        @the_shootguy

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Risikogruppe Raucher Lars Gebauer <lgebauer@live.de> - 2020-06-04 20:27 +0200
  Re: Risikogruppe Raucher Shinji Ikari <shinji@gmx.net> - 2020-06-04 20:55 +0200
    Re: Risikogruppe Raucher Shinji Ikari <shinji@gmx.net> - 2020-06-05 00:36 +0200
  Re: Risikogruppe Raucher Stephan Bumberger <bumberger@gmx.de> - 2020-06-04 21:34 +0200
    Re: Risikogruppe Raucher Hermann Riemann <nospam.ng@hermann-riemann.de> - 2020-06-10 06:27 +0200
  Re: Risikogruppe Raucher Frank Hucklenbroich <Hucklenbroich01@aol.com> - 2020-06-04 22:12 +0200
  Re: Risikogruppe Raucher Lars Gebauer <lgebauer@live.de> - 2020-06-05 10:57 +0200
  Re: Risikogruppe Raucher herwig.huener@t-online.de - 2020-06-05 02:26 -0700

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