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Re: Iron In Periodontitis

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Steven Bornfeld <dentaltwin@earthlink.net> wrote:
> On 12/9/2021 3:47 AM, tom hennessy wrote:
>> High serum iron markers are associated with periodontitis in
>> postmenopausal women: a population-based study (NHANES III)
>> Susilena Arouche Costa 1, Cecilia Claudia Costa Ribeiro 2,
>> Ana Regina Oliveira Moreira 3, Soraia de F??tima Carvalho Souza 4
>> J Clin Periodontol . 2021 Dec 8. doi: 10.1111/jcpe.13580.\
>> 
>> Abstract
>> Aim: To investigate the association between increased serum markers
>> of iron (ferritin and transferrin saturation) and the severity and
>> extent of periodontitis in postmenopausal women.
>> 
>> Methods: Data from 982 postmenopausal women participating in
>> NHANES III were analyzed. Exposures were high ferritin (300 g/mL)
>> and transferrin saturation (45%). The primary outcome was
>> moderate/severe periodontitis defined according to Centers for
>> Disease Control and Prevention and the American Academy of
>> Periodontology. The extent of periodontitis was also assessed
>> as outcome: proportion of sites affected by clinical attachment
>> loss 4mm and probing depth 4mm. Crude and adjusted Prevalence
>> Ratio (PR) and Mean Ratio (MR) were estimated using Poisson
>> Regression.
>> 
>> Results: The prevalence of moderate/severe periodontitis was 27.56%.
>> High ferritin was associated with moderate/severe periodontitis in
>> the crude (PR 1.55, p = 0.018) and in the final adjusted model
>> (PR 1.53, p = 0.008). High ferritin and transferrin saturation levels
>> were associated with a higher proportion of sites with clinical
>> attachment loss 4mm (p < 0.05).
>> 
>> Conclusion: The increasing serum iron markers seem to contribute
>> to periodontitis severity and extent in postmenopausal women.
>> 
>> PMID: 34879443 DOI: 10.1111/jcpe.13580
>> Tom
> 
> 
> 1) Increase in ferritin has potential causes other than diet
> 2) Association does not indicate causation.

Actually, re item 2, it kind of does. Not direct A-->B causation,
but indirect C-->A && C-->B, i.e., a (so far undetected) common
cause for both A and B. The typical paradigmatic example given
is the 100% correlation between the monsoon season in India,
which always begins several weeks after flowers bloom in upstate
New York. So NY flowers cause India's monsoons? No, but the Earth's
orbit around the Sun causes both. So the point here would be to
suggest that maybe (emphasize maybe) whatever (besides diet, as per
your item 1) is causing ferritin increase might also be responsible
for the periodontitis increase. At least, might be worth looking at.
-- 
John Forkosh  ( mailto:  j@f.com  where j=john and f=forkosh )

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Iron In Periodontitis tom hennessy <teamtanner@hotmail.com> - 2021-12-09 00:47 -0800
  Re: Iron In Periodontitis Steven Bornfeld <dentaltwin@earthlink.net> - 2021-12-09 10:46 -0500
    Re: Iron In Periodontitis John Forkosh <forkosh@panix.com> - 2021-12-10 08:12 +0000
      Re: Iron In Periodontitis Steven Bornfeld <dentaltwin@earthlink.net> - 2021-12-10 22:41 -0500
        Re: Iron In Periodontitis John Forkosh <forkosh@panix.com> - 2021-12-12 16:17 +0000

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