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Re: Research: Comprehensive guideline on using biomarkers for monitoring Crohn's disease

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On Friday, November 17, 2023 at 4:19:50 PM UTC-8, Luke Luke wrote:
> https://www.sciencedaily.com/releases/2023/11/231117102543.htm 
> 
> Article: https://www.gastrojournal.org/article/S0016-5085(23)05064-3/fulltext 
> 
> Comprehensive guideline on using biomarkers for monitoring Crohn's disease 
> Date: November 17, 2023 
> Source: American Gastroenterological Association 
> Summary: 
> New AGA guideline outlines reliable blood and stool tests to monitor inflammation that can reduce how often patients need invasive endoscopy. 
> 
> The American Gastroenterological Association (AGA) released a new evidence-based guideline recommending the use of blood and stool-based biomarkers to help manage Crohn's disease, a type of inflammatory bowel disease (IBD). IBD is estimated to affect 2.74 million people in the U.S. The guideline was published today in Gastroenterology. 
> 
> Biomarkers are blood or stool tests that can give more information on an underlying disease process. In the context of IBD, biomarkers such as C-reactive protein (CRP) in blood and fecal calprotectin (FCP) in stool, can measure levels of inflammation. These levels can help doctors assess whether a patient's Crohn's disease is active or in remission. 
> 
> AGA recommends the use of biomarkers in addition to colonoscopy and imaging studies. 
> 
> "Patients' symptoms do not always match endoscopic findings, so biomarkers are a useful tool to understand and monitor the status of inflammation and guide decision making in patients with Crohn's disease," says guideline author Siddarth Singh, MD, MS, University of California, San Diego. 
> 
> For patients in remission: 
> 
> Check CRP and FCP every six to 12 months. 
> 
> These tests work best if CRP and FCP levels have previously matched with disease activity seen on endoscopic assessment. 
> 
> For patients experiencing active symptoms: 
> 
> Check CRP and FCP every two to four months for patients experiencing an increase in symptoms (diarrhea and abdominal pain) to guide treatment adjustments. 
> 
> Before making any major treatment plan changes, consider repeating endoscopic or radiologic assessments. 
> 
> For patients after surgery: 
> 
> FCP may be useful to monitor patients at low risk for disease recurrence. 
> 
> However, radiologic or endoscopic assessment should be performed when a post-operative recurrence is suspected rather than relying on biomarkers. 
> 
> "Based on this guideline, biomarkers are no longer considered experimental and should be an integral part of IBD care," says guideline author Ashwin Ananthakrishnan, MBBS, MPH, Massachusetts General Hospital. 
> 
> This is a win for Crohn's disease patients. Biomarkers are usually easier to obtain, less invasive, more cost-effective than frequent colonoscopies and can be assessed more frequently for tighter disease control and better long-term outcomes in Crohn's disease." 
> 
> ... 
> 
> Journal Reference: 
> 
> Ashwin N. Ananthakrishnan, Jeremy Adler, Karen A. Chachu, Nghia H. Nguyen, Shazia M. Siddique, Jennifer M. Weiss, Shahnaz Sultan, Fernando S. Velayos, Benjamin L. Cohen, Siddharth Singh. AGA Clinical Practice Guideline on the Role of Biomarkers for the Management of Crohn’s Disease. Gastroenterology, 2023; 165 (6): 1367 DOI: 10.1053/j.gastro.2023.09.029 
> 
> -- 
> Luke
Thanks--
sort of off topic.  My son has crohns and isn't doing well.  My wife has RA and I have psoriasis.  In desperation, we tried something mentioned on a psoriasis site--a grounding mat.  Basically, it's a rubber mat plugged into only the ground hole of an electric outlet.  It seems to work--not a cure, but definitely lessens the problems.  When I told this to my dermatologist, he rolled his eyes--as you are probably also doing. It might be worth trying for others.

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Research: Comprehensive guideline on using biomarkers for monitoring Crohn's disease Luke Luke <zumone2002@protonmail.com> - 2023-11-17 16:19 -0800
  Re: Research: Comprehensive guideline on using biomarkers for monitoring Crohn's disease Mel <melvynnc@gmail.com> - 2023-11-18 08:27 -0800
    Re: Research: Comprehensive guideline on using biomarkers for monitoring Crohn's disease Luke Luke <zumone2002@protonmail.com> - 2023-11-19 09:21 -0800
      Re: Research: Comprehensive guideline on using biomarkers for monitoring Crohn's disease Mel <melvynnc@gmail.com> - 2023-11-20 07:39 -0800
        Re: Research: Comprehensive guideline on using biomarkers for monitoring Crohn's disease Luke Luke <zumone2002@protonmail.com> - 2024-01-03 09:40 -0800

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