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LORAZEPAM

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GENERIC NAME: lorazepam
BRAND NAME: Ativan
DRUG CLASS AND MECHANISM: Lorazepam is a drug used for treating
anxiety. It is in the benzodiazepine family, the same family that
includes diazepam (Valium), alprazolam (Xanax), clonazepam (Klonopin),
flurazepam (Dalmane), and others. It is thought that excessive
activity of nerves in the brain may cause anxiety and other
psychological disorders. Gamma-aminobutyric acid (GABA) is a
neurotransmitter, a chemical that nerves in the brain use to send
messages to one another. GABA reduces the activity of nerves in the
brain. Lorazepam and other benzodiazepines may act by enhancing the
effects of GABA in the brain. Because lorazepam is removed from the
blood more rapidly than many other benzodiazepines, there is less
chance that lorazepam concentrations in blood will reach high levels
and become toxic. Lorazepam also has fewer interactions with other
medications than most of the other benzodiazepines. The FDA approved
lorazepam in March 1999.
PRESCRIPTION: Yes
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets: 0.5, 1, and 2 mg. Oral solution: 2 mg/ml.
Injection: 2 mg/ml and 4 mg/ml
STORAGE: Tablets should be kept at room temperature 15-30°C (59-86°F).
Oral solutions should be refrigerated at 2-8°C (36-46°F). Injectable
solutions should be refrigerated.
PRESCRIBED FOR: Lorazepam is used for the management of anxiety
disorders, the short-term relief of symptoms of anxiety or anxiety
associated with depression. The effectiveness of lorazepam and other
benzodiazepines has not been adequately studied for treatment beyond 4
months. Lorazepam is effective for insomnia, panic attacks, and is
used in combination with other medications to prevent nausea and
vomiting resulting from chemotherapy. Lorazepam also is administered
before anesthesia and used for prevention and treatment of alcohol
withdrawal.
DOSING: The dose of lorazepam is tailored to the patient's needs. The
usual dose for treating anxiety is 2-3 mg/day given in two or three
divided doses. Insomnia is treated with 2-4 mg given at bedtime.

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DRUG INTERACTIONS: Lorazepam and all benzodiazepines interact with
other medications and drugs that slow the brain's processes such as
alcohol, barbiturates, narcotics, and tranquilizers. There have been
cases of marked sedation when lorazepam was given to patients taking
the tranquilizer loxapine (Loxitane); it is unclear if there is a drug
interaction, but caution should be used if lorazepam and loxapine are
used together.

PREGNANCY: Lorazepam and other benzodiazepines have been associated
with fetal damage, including congenital malformations, when taken by
pregnant women in their first trimester. Lorazepam is best avoided if
at all possible in the first trimester and probably throughout
pregnancy.

NURSING MOTHERS: It is not known if lorazepam is secreted in breast
milk.

SIDE EFFECTS: The most common side effects associated with lorazepam
are sedation (15.9% of patients), dizziness (6.9% of patients),
weakness, and unsteadiness. Other side effects include a feeling of
depression, loss of orientation, headache, and sleep disturbance.

Like all benzodiazepines, lorazepam can cause physical dependence.
Suddenly stopping therapy after a few months of daily therapy may be
associated with a feeling of loss of self-worth, agitation, and
insomnia. If lorazepam is taken continuously for longer than a few
months, stopping therapy suddenly may produce seizures, tremors,
muscle cramping, vomiting, and sweating.

Reference: FDA Prescribing Informationlorazepam

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lorazepam Oral
Important Note

Brand Name(s): Ativan
Review this Drug356 User ReviewsView Images
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose
lorazepam Oral Warnings



lorazepam Oral Uses

This medication is used to treat anxiety. Lorazepam belongs to a class
of drugs known as benzodiazepines which act on the brain and nerves
(central nervous system) to produce a calming effect. This drug works
by enhancing the effects of a certain natural chemical in the body
(GABA).

OTHER USES: This section contains uses of this drug that are not
listed in the approved professional labeling for the drug but that may
be prescribed by your health care professional. Use this drug for a
condition that is listed in this section only if it has been so
prescribed by your health care professional.

If directed by your doctor, this drug may also be used to reduce the
symptoms of alcohol withdrawal, to prevent nausea and vomiting due to
chemotherapy, and for sleeping trouble (insomnia).
How to use lorazepam Oral

Take this medication by mouth with or without food as directed by your
doctor. Dosage is based on your medical condition and response to
therapy.

If directed by your doctor, use this medication regularly in order to
get the most benefit from it. To help you remember, use it at the same
time(s) each day.

This medication may cause withdrawal reactions, especially if it has
been used regularly for a long time or in high doses (more than 1-4
weeks) or if you have a history of alcoholism, drug abuse, or
personality disorder. In such cases, withdrawal symptoms (such as
seizures, trouble sleeping, mental/mood changes, increased reactions
to noise/touch/light, nausea, vomiting, diarrhea, loss of appetite,
stomach pain, hallucinations, numbness/tingling of arms and legs,
muscle pain, fast heartbeat, short-term memory loss, and very high
fever) may occur if you suddenly stop using this medication. To
prevent withdrawal reactions, your doctor may reduce your dose
gradually. Consult your doctor or pharmacist for more details, and
report any withdrawal reactions immediately.

Though it is very unlikely to occur, this medication can also result
in abnormal drug-seeking behavior (addiction/habit forming). Do not
increase your dose, take it more frequently, or use it for a longer
time than prescribed. Properly stop the medication when so directed.
This will lessen the chances of becoming addicted.

Do not suddenly stop using this drug without your doctor's approval.
Some conditions may become worse when the drug is abruptly stopped.
Your dose may need to be gradually decreased.

When used for an extended time, this medication may not work as well
and may require different dosing. Talk with your doctor if this
medication stops working well. Do not increase your dose without first
talking to your doctor.

Inform your doctor if your condition persists or worsens.

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