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Xref: csiph.com comp.lang.python:27525

By chance and luckily, first attempt.

IDLE, Windows 7.0 Pro 32, Pentium Dual Core 2.6, RAM 2 Go

Py 3.2.3
>>> timeit.repeat("('=80'*100+'=80'*100).replace('=80', '=9C')")
[1.6939567134893707, 1.672874290786993, 1.6761219212298073]

Py 3.3.0b2
>>> timeit.repeat("('=80'*100+'=80'*100).replace('=80', '=9C')")
[7.924470733910917, 7.8554985620787345, 7.878623849091914]


Console

c:\python32\python -m timeit "('=80'*100+'=80'*100).replace('=80'
, '=9C')"
1000000 loops, best of 3: 1.48 usec per loop
c:\python33\python -m timeit "('=80'*100+'=80'*100).replace('=80'
, '=9C')"
100000 loops, best of 3: 7.62 usec per loop

Note
The used characters are not members of the latin-1 coding
scheme (btw an *unusable* coding).
They are however charaters in cp1252 and mac-roman.

jmf