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From: "Elias Fotinis" <efotinis@yahoo.com>
Subject: Re: Windows Registry Keys
Date: Thu, 19 May 2011 23:05:18 +0300
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On Thu, 19 May 2011 21:03:34 +0300, Mathew <myeates@jpl.nasa.gov> wrote:

> I have installed a new version of Python27 in a new directory. I want to get
> this info into the registry so, when I install Numpy, it will use my new
> Python

If I understand correctly (you have multiple Python 2.7 installations and what to make this new one the current), you should change this key:
   HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\Python\PythonCore\2.7\InstallPath

(ignore "Wow6432Node" if you are not on 64-bit Windows)

That'd would probably be enough for the Numpy installer. I assume you are aware about the changes that may be required to the PATH and file associations.